Axonal projections were labeled with stereotaxic injections of viral tracers in mouse models of Alzheimer’s disease and their aged littermates. Whole brain axonal trajectories were quantified using the standardized platform for the Allen Mouse Brain Connectivity Atlas to generate a database of neural projections in aging and diseased mice. Amyloid beta plaques were also labeled in mice with amyloid pathology, and brain-wide plaque density was quantified using an automated pipeline. This dataset can be compared with the projections of young adult (p56) mice in the Allen Mouse Brain Connectivity Atlas to identify differences in anatomy and connectivity that occur in aging and Alzheimer’s disease.
These data were generated from stereotaxic injections into the following Alzheimer’s disease and frontotemporal dementia mouse lines.
Mouse Line
Description
Source
APP/PS1
Express chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe)with the Swedish mutations (K595N/M596L) and a mutant human presenilin 1 (PS1-dE9). Expression is driven by the mouse prion protein promotor (moPrP).
hAPP-J20
Express a mutant form of the human amyloid protein precursor bearing both the Swedish (K670N/M671L) and the Indiana (V717F) mutations (APPSwInd).Expression is driven by thehuman platelet-derived growth factor beta polypeptide (PDGFb) promoter.
rTg4510
ThesebitransgenicmiceexpresstauP301Lin forebrain.ThetetO-MAPT*P301L transgene has the Tet-responsive element (TRE ortetO) and mouse prion protein promoter sequences (PrPorPrnp) directing expression of the P301L mutant variant of human four-repeat microtubule-associated protein tau (4R0N tauP301L). It is crossed withCaMK2a-tTAmice so that expression of tauP301Lis driven by the CaMK2apromotor in the absence of doxycycline.
Tg2576
Overexpression of the human APP gene encoding the APP695.SWE mutation (K670N and M671L).The construct contained the APP gene fused to the hamster prion protein promoter(haPrP).
There are five experiments in this dataset:
This project was supported by the National Institute on Aging and the National Institutes of Health by Award Number R01AG047589. Its contents are solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
