To investigate the diversity of cell types across the mouse neocortex at the transcriptional level, 15,413 cells were profiled from the primary visual cortex (VISp), and 10,068 cells from the anterior lateral motor cortex (ALM). These two regions represent distant poles of the neocortex and perform distinct functions. Analysis of these transcriptional profiles reveals 133 transcriptomic cell types. These types are divided into 61 GABAergic neuron types and 16 non-neuronal types, most of which are shared across both cortical areas, and 56 glutamatergic neuron types, most of which segregate by cortical region.
Taxonomy Name: 20181031_Adult_Mouse_VISp-ALM_SMARTseq
Taxonomy Description: Mouse V1 & ALMTaxonomy
Species: Mouse
Version: 1.0.0
CCN Number: CCN201810310
AIT Number: 2.1.1
Shared and distinct transcriptomic cell types across neocortical areas
Explore the data using the RNA-Seq Data Navigator
Explore the data using the UCSC Genome Browser
View the clustering & analysis code on GitHub
An integrated taxonomy of the whole mouse brain built upon two publicly released transcriptionally defined WMB taxonomies from Allen Institute for Brain Science and Broad Institute.
A hierarchical cell type taxonomy comprising 379 transcriptomic types found in the mouse isocortex and hippocampal formation
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
