Processing, Registration, Integration

MIRACL

MIRACL is an automated software resource which collates histologically cleared volumes alongside connectivity atlases and MRI, enabling analysis of histological features across multiple fiber tracts and networks, and their correlation with in vivo biomarkers. This tool serves as an open source pipeline for automated registration of mice clarity data to Allen reference atlas.

Link to the tool

More information

  • RRID:SCR_020945
  • Software Type:data registration software
  • Modality:histology, image registration
  • Allen Resource(s) Utilized:Allen Mouse Brain Reference Atlas, Allen Mouse Connectivity Atlas
  • Author(s):Magen Goubran
  • Year Released:2023

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BREIN can be used to analyzes RNA in-situ hybridization or immunohistochemical images. It can register images to Allen reference atlas and calculates the signal intensity per brain region, and outputs a spreadsheet of the results.

MENGA: Multimodal Environment for Neuroimaging and Genomic Analysis
MENGA: Multimodal Environment for Neuroimaging and Genomic Analysis

MENGA is a platform for the integration of imaging data and Allen Human Brain Atlas mRNA data. MENGA investigates correlation patterns between various imaging modalities and gene expression profiles based on the Allen Brain Atlas.

Nutil
Nutil

Nutil is a data processing resource which simplifies and streamlines the pre-and-post processing of 2D brain image data from both the mouse and rat. To use Nutil, the user specifies the input and output parameters in the GUI.