Processing, Registration, Integration

Process Genes List

ProcessGeneLists (PGL) is an R package which links genetics and human brain imaging by using genes associated with a disease and calculating a normalized mRNA expression average of those genes in each brain region. By uploading lists of genes and brain regions of interest, this package will return a csv with the results.

Link to the tool | Relevant publication

More information

  • RRID:SCR_023823
  • Software Type:data integration, data analysis software
  • Modality:gene expression, neuroanatomy
  • Allen Resource(s) Utilized:Allen Human Brain Atlas
  • Author(s):Guillermo F. Pollete, Savannah N. Gosnell, Matthew Meyer, Mary Fang, Tien Nquyen, Michelle A. Patriquin, David Nielsen, Thomas Kosten, Ramiro Salas
  • Year Released:2023

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BREIN (Brain Region Expression Intensity Neuroanalysis)
BREIN (Brain Region Expression Intensity Neuroanalysis)

BREIN can be used to analyzes RNA in-situ hybridization or immunohistochemical images. It can register images to Allen reference atlas and calculates the signal intensity per brain region, and outputs a spreadsheet of the results.

MENGA: Multimodal Environment for Neuroimaging and Genomic Analysis
MENGA: Multimodal Environment for Neuroimaging and Genomic Analysis

MENGA is a platform for the integration of imaging data and Allen Human Brain Atlas mRNA data. MENGA investigates correlation patterns between various imaging modalities and gene expression profiles based on the Allen Brain Atlas.

Nutil
Nutil

Nutil is a data processing resource which simplifies and streamlines the pre-and-post processing of 2D brain image data from both the mouse and rat. To use Nutil, the user specifies the input and output parameters in the GUI.