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Seattle Alzheimer’s Disease Brain Cell Atlas

The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) consortium strives to gain a deep molecular and cellular understanding of the early pathogenesis of Alzheimer’s disease. We provide free, open resources to the scientific community.

What is SEA-AD
Learn more about the SEA-AD consortium, our approach, and the donor cohort.

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Our Resources
Explore single cell and spatial -omics, neuropathology, and donor demographics using free, interactive tools.
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Our Science
Access our latest published work describing cellular and molecular changes in AD progression.
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Our Data
Access to raw and processed data, demographic information, quantifications, scores, conversion tables, documentation, taxonomies and methods information.
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Research reported here was supported by the National Institute On Aging of the National Institutes of Health under Award Number U19AG060909. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Study data were generated from postmortem brain tissueobtained from the University of Washington BioRepository and Integrated Neuropathology (BRaIN) laboratory and Precision Neuropathology Core, which is supported by the NIH grants for the UW Alzheimer's Disease Research Center (NIA grants: P50AG005136 and P30AG066509) and the Adult Changes in Thought Study (NIA grants: U01AG006781 and U19AG066567).

The ACT study is a longitudinal population-based prospective cohort study of brain aging and incident dementia in the Seattle metropolitan area. ACT is a repository at the Kaiser Permanente Washington Health Research Institute, which has established policies and procedures for sharing data with external investigators. Data available from this study web site do not require any additional Institutional Review Board (IRB) approval or permissions. Linking those data with other ACT study or Kaiser Permanente Washington data would require additional review.All ofthose steps are initiated after contacting KPWA.actproposals@kp.org.