This study used single cell and spatial genomics tools alongside quantitative neuropathology to understand the impact of Alzheimer's disease progression on cell types in middle temporal gyrus and dorsolateral prefrontal cortex. We mapped >1.2 million cells per region from 84 aged donors to 125 transcriptional types and showed which cell types changed in their abundance and gene expression with increasing disease pathology. This manuscript accompanies a freely available public resource to explore these data and to accelerate progress in AD research at SEA-AD.org.
Taxonomy Name: 20230505_SEAAD-Adult_Human_MTG_10X
Taxonomy Description: MTG - 10x SEA-AD
Species: Human
Version: 1.0.0
CCN Number: CCN20230505
AIT Number: 31
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Integrated multimodal cell atlas of Alzheimer’s disease
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Taxonomy of human middle temporal gyrus generated with SMART-seq data in 2019
This study used single cell transcriptomics and performed cellular characterization of eight areas in human neocortex to better understand cortical areal specialization.
This study used single-nucleus RNA sequencing to systematically survey cells across the entire adult human brain.
