This study used single cell transcriptomics and performed cellular characterization of eight areas in human neocortex to better understand cortical areal specialization. This work identified 24 highly consistent cell subclasses across structures. However, proportions of excitatory neuron subclasses varied substantially, and some glia showed distinct layer organization across areas. Primary visual cortex showed characteristic organization with major changes both excitatory and inhibitory types, reflecting the importance of vision for humans.
Taxonomy Name: 20191012_Adult_Human_Neocortex_SMARTseq
Taxonomy Description: Multiple Cortical Areas - SMART-seq
Species: Human
Version: 1.0.0
CCN Number: CCN201910121
AIT Number: 105.0
Transcriptomic cytoarchitecture reveals principles of human neocortex organization
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Taxonomy of human middle temporal gyrus generated with SMART-seq data in 2019
A taxonomy of the human middle temporal gyrus developed as part of the Seattle Alzheimer's Disease Brain Cell Atlas
This study used single-nucleus RNA sequencing to systematically survey cells across the entire adult human brain.
